Comparative CYP3A4 Inhibitory Effects of Venlafaxine, Fluoxetine, Sertraline, and Nefazodone in Healthy Volunteers

@article{DeVane2004ComparativeCI,
  title={Comparative CYP3A4 Inhibitory Effects of Venlafaxine, Fluoxetine, Sertraline, and Nefazodone in Healthy Volunteers},
  author={C. Lindsay DeVane and Jennifer L. Donovan and Heidi L. Liston and John Seth Markowitz and Kenneth T. Cheng and Samuel Craig Risch and L. Willard},
  journal={Journal of Clinical Psychopharmacology},
  year={2004},
  volume={24},
  pages={4-10}
}
Abstract: An antidepressant for use in the patient receiving concomitant drug treatment, over-the-counter medications, or herbal products should lack cytochrome P-450 (CYP) 3A4 inductive or inhibitory activity to provide the least likelihood of a drug-drug interaction. This study addresses the potential of 4 diverse antidepressants (venlafaxine, nefazodone, sertraline, and fluoxetine) to inhibit or induce CYP3A4. In a 4-way crossover design, 16 subjects received clinically relevant doses of… 
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