Comparative Biochemistry of Tau in Progressive Supranuclear Palsy, Corticobasal Degeneration, FTDP‐17 and Pick's Disease

@article{Bue1999ComparativeBO,
  title={Comparative Biochemistry of Tau in Progressive Supranuclear Palsy, Corticobasal Degeneration, FTDP‐17 and Pick's Disease},
  author={Luc Bu{\'e}e and André Delacourte},
  journal={Brain Pathology},
  year={1999},
  volume={9}
}
Neurodegenerative disorders referred to as tauopathies have cellular hyperphosphorylated tau protein aggregates in the absence of amyloid deposits. Comparative biochemistry of tau aggregates shows that they differ in both phosphorylation and content of tau isoforms. The six tau isoforms found in human brain contain either three (3R) or four microtubule‐binding domains (4R). In Alzheimer's disease, all six tau isoforms are abnormally phosphorylated and aggregate into paired helical filaments… 
Pathological Tau Phenotypes: The Weight of Mutations, Polymorphisms, and Differential Neuronal Vulnerabilities
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TLDR
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    Neuropathology : official journal of the Japanese Society of Neuropathology
  • 2006
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TLDR
The anatomical distribution of tau pathology determines the clinical presentation of PSP and CBD, as well as PiD, and the basis for this selective cortical vulnerability in FTLD-tau is unknown.
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TLDR
Tau pathology in glial cells largely parallels, but is not identical to, that in neurons in many tauopathies, and disease-specific astroglial phenotypes depend on the primary amino acid sequence of tau.
Human Tau Isoforms and Proteolysis for Production of Toxic Tau Fragments in Neurodegeneration
TLDR
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Pathological inclusion bodies in tauopathies contain distinct complements of tau with three or four microtubule‐binding repeat domains as demonstrated by new specific monoclonal antibodies
TLDR
Two monoclonal antibodies, RD3 and RD4, are developed that effectively distinguish these closely related tau isoforms that are useful tools for analysing t Tau isoform expression and distribution as well as pathological changes in the human brain.
Increase in the relative expression of tau with four microtubule binding repeat regions in frontotemporal lobar degeneration and progressive supranuclear palsy brains
TLDR
Examination of tau mRNA and protein levels in frontal cortex from 15 sporadic FTLD, 21 PSP, 5 CBD, 15 Alzheimer’s disease (AD) and 16 control brains demonstrated increased but largely variable 4R tau/3R t Tau mRNA ratios, suggesting heterogeneous pathophysiological processes within these disorders.
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