Comparative Biochemistry of Tau in Progressive Supranuclear Palsy, Corticobasal Degeneration, FTDP‐17 and Pick's Disease

  title={Comparative Biochemistry of Tau in Progressive Supranuclear Palsy, Corticobasal Degeneration, FTDP‐17 and Pick's Disease},
  author={L. Bu{\'e}e and A. Delacourte},
  journal={Brain Pathology},
  • L. Buée, A. Delacourte
  • Published 1999
  • Biology, Medicine
  • Brain Pathology
  • Neurodegenerative disorders referred to as tauopathies have cellular hyperphosphorylated tau protein aggregates in the absence of amyloid deposits. Comparative biochemistry of tau aggregates shows that they differ in both phosphorylation and content of tau isoforms. The six tau isoforms found in human brain contain either three (3R) or four microtubule‐binding domains (4R). In Alzheimer's disease, all six tau isoforms are abnormally phosphorylated and aggregate into paired helical filaments… CONTINUE READING
    322 Citations
    Pathological Tau Phenotypes: The Weight of Mutations, Polymorphisms, and Differential Neuronal Vulnerabilities
    • 25
    Relationship of the extended tau haplotype to tau biochemistry and neuropathology in progressive supranuclear palsy
    • 69
    Cellular tau pathology and immunohistochemical study of tau isoforms in sporadic tauopathies
    • M. Yoshida
    • Biology, Medicine
    • Neuropathology : official journal of the Japanese Society of Neuropathology
    • 2006
    • 95
    Neuropathology of Frontotemporal Lobar Degeneration-Tau (FTLD-Tau)
    • 198
    Glial and neuronal tau pathology in tauopathies: characterization of disease-specific phenotypes and tau pathology progression.
    • 116
    • PDF
    Protein Tau: Prime Cause of Synaptic and Neuronal Degeneration in Alzheimer's Disease
    • 53
    • PDF


    Neurofibrillary Degeneration in Progressive Supranuclear Palsy and Corticobasal Degeneration
    • 267
    • PDF
    Specific Pathological Tau Protein Variants Characterize Pick's Disease
    • 202
    • PDF
    Neurofibrillary Tangles in Progressive Supranuclear Palsy Contain the Same Tau Epitopes Identified in Alzheimer's Disease PHFtau
    • 63
    • PDF
    Mutation in the tau gene in familial multiple system tauopathy with presenile dementia.
    • 1,345
    • Highly Influential
    • PDF