• Corpus ID: 53297148

Comparative Analysis of the Main Nasal Cavity and the Paranasal Sinuses in Chronic Rhinosinusitis: An Anatomic Study of Maximal Medical Therapy

  title={Comparative Analysis of the Main Nasal Cavity and the Paranasal Sinuses in Chronic Rhinosinusitis: An Anatomic Study of Maximal Medical Therapy},
  author={Satyan B. Sreenath and Julia S. Kimbell and Saikat Basu and Andrew J Coniglio and Tatayana E. Fontenot and Brian D. Thorp and Charles S. Ebert and Brent A Senior and Adam Mikial Zanation},
  journal={arXiv: Medical Physics},
Objective: Minimal literature exists investigating changes in inflammation with respect to the main nasal cavity (MNC) and paranasal sinuses (PS) before and after maximal medical therapy (MMT) for chronic rhinosinusitis (CRS). We hypothesized that MMT produces a differential level of change in the volume of air space in the MNC and PS, and that resolution of mucosal disease associated with the osteomeatal complex (OMC) influences clinical response to MMT. Study Design: Retrospective study of 12… 
1 Citations

Numerical evaluation of spray position for improved nasal drug delivery

A new usage strategy for nasal sprays available over-the-counter, that registers an average 8-fold improvement in topical delivery of drugs at diseased sites, when compared to prevalent spray techniques is identified.



Significance of osteomeatal complex obstruction.

Classic teaching suggests that disease in the osteomeatal complex (OMC) plays a pivotal role in the establishment of chronic rhinosinusitis (CRS), and this hypothesis was sought to test.

Computed Tomography Scans as an Objective Measure of Disease Severity in Chronic Rhinosinusitis

Computerized CT analysis provides the most comprehensive, objective, and reproducible method of measuring disease severity and is very sensitive to change induced by treatment intervention.

Efficacy of Targeted Medical Therapy in Chronic Rhinosinusitis, and Predictors of Failure

Background No standardized medical therapy for chronic rhinosinusitis (CRS) is universally accepted. Success of medical therapy is reportedly 50% to 88%, but studies differ in inclusion criteria,

A Retrospective Analysis of Treatment Outcomes and Time to Relapse after Intensive Medical Treatment for Chronic Sinusitis

Intensive medical treatment resulted in symptomatic and radiographic improvement in chronic sinusitis, and the majority of patients remained free of a relapse for >8 weeks, and a prospective study of treatment outcomes from intensive medical treatment appears to be warranted.

Efficacy of medical therapy in treatment of chronic rhinosinusitis

In approximately one-third of patients with CRS, medical therapy improved symptoms sufficiently so that surgical therapy was avoided, and the proportion of patients treated medically who responded sufficiently well so that surgery was not required.

American Rhinologic Society Member Survey on “Maximal Medical Therapy” for Chronic Rhinosinusitis

Oral antibiotics (median, 3.1–4 weeks) and nasal steroids are used >90% of the time by a majority of ARS members for maximal medical treatment of CRS.

Effects of endoscopic sinus surgery and delivery device on cadaver sinus irrigation

When are we operating for chronic rhinosinusitis? A systematic review of maximal medical therapy protocols prior to endoscopic sinus surgery

A systematic review of the various MMT criteria employed prior to considering ESS for chronic rhinosinusitis in patients with CRS is described.

Oral steroids and doxycycline: two different approaches to treat nasal polyps.

Pre‐ and Postoperative Sinus Penetration of Nasal Irrigation

A critical ostial size at which douching solution reliably enters the sinus cavities is determined, which is likely to improve long‐term outcomes of chronic rhinosinusitis.