Comparative Analysis of the Anxiolytic Effects of 3-Hydroxypyridine and Succinic Acid Derivatives

@article{Volchegorskii2015ComparativeAO,
  title={Comparative Analysis of the Anxiolytic Effects of 3-Hydroxypyridine and Succinic Acid Derivatives},
  author={I A Volchegorskii and I. Yu. Miroshnichenko and L. M. Rassokhina and R. M. Faizullin and M. P. Malkin and Kateryna Pryakhina and Aleksandra V. Kalugina},
  journal={Bulletin of Experimental Biology and Medicine},
  year={2015},
  volume={158},
  pages={756-761}
}
Threefold administration of 3-hydroxypyridine derivatives emoxipine and mexidol in optimal doses corresponding to the therapeutic dose range for humans produced an anxiolytic effect and stimulated risk behavior in the elevated plus maze test in rats. These effects were most pronounced after injection of 3-hydroxypyridine derivative emoxipine. Combination of 3-hydroxypyridine cation and succinate anion in the mexidol structure led to attenuation of the anxiolytic effect and less pronounced… 
5 Citations
Anxiolytic and Antidepressant Actions of Emoxypine, Reamberin, and Mexidol in Experimental Diabetes Mellitus
TLDR
The most marked anxiolytic potential was demonstrated for emoxypine, which was the only one of the study drugs decreasing the signs of anxiety not only in comparison with the alloxan diabetes control group, but also relative to the intact control group.
[Anxiolytic and antidepressant effects of emoxipine, reamberin and mexidol in experimental diabetes mellitus].
TLDR
The most pronounced anxiolytic potential was demonstrated for emoxipine that emerged as the only medication in the study that reduced manifestations of anxiety not only in comparison with 'alloxan diabetes-control' groups but also in comparison to 'intact control'.
Correction of mitochondrial dysfunction by succinic acid derivatives under experimental cerebral ischemia conditions
TLDR
The studied succinic acid derivatives contribute to the restoration of mitochondrial function in cerebral ischemia conditions, while the most effective dose can be considered to be 100 mg/kg.
Ovicidal activity of succinic acid isolated from sisal waste ("Agave sisalana") against gastrointestinal nematodes of goats
EnglishThis study was conducted to evaluate the in vitro anthelmintic activity of the succinic acid (SA) isolated from sisal waste against gastrointestinal nematodes of goats, using the egg hatching

References

SHOWING 1-10 OF 19 REFERENCES
Anti-Alcohol and Anxiolytic Properties of a New Chemical Entity, GET73
TLDR
The results of the present study suggest that GET73 has a multifaceted pharmacological profile, including the capacity to reduce alcohol drinking and anxiety-related behaviors in rats.
Effects of 3-Hydroxypyridine Derivatives and Succinic Acid on Endometrial Leukocyte Infiltration, Cytokinemia and Related Affective Symptoms during Exacerbation of the Chronic Inflammation of the Uterus and Adnexa
We studied the effects of original Russian derivatives of 3-hydroxypyridine and succinic acid (emoxipine, reamberin and mexidol) on the time course of endometrial leukocyte infiltration, blood levels
The use of the elevated plus maze as an assay of anxiety-related behavior in rodents
The elevated plus maze is a widely used behavioral assay for rodents and it has been validated to assess the anti-anxiety effects of pharmacological agents and steroid hormones, and to define brain
Molecular Neuropharmacology: A Foundation for Clinical Neuroscience
An engagingly written, vibrantly illustrated reference that expertly links neurobiology, clinical psychiatry, and neurology Molecular Neuropharmacology first reviews the fundamental biochemistry of
Methods of Behavior Analysis in Neuroscience
TLDR
Transgenic Mouse Models of Alzheimer's Disease: Behavioral Testing and Considerations, K.J. Bryan, H.A. Smith, and G.D. Rosecrans Anxiety-Related Behaviors in Mice, and The Revival of Scopolamine Reversal for the Assessment of Cognition-Enhancing Drugs, J. Buccafusco Index.
[The regulation of experiments on animals--ethics, legislation and alternatives].
Legislation and rules for animal experiments in many countries are proposed. Activities of international and national organizations, committees and administrative authorities are described. The
Buccafusco, Methods of Behavioral Analysis in Neuroscience, London; New York
  • 2009
R . A . Kopaladze , Uspekhi Fiziol . Nauk , 29 , No . 4 , 74 - 92 ( 1998 ) . 7 . A . B . Smulevich , Depressions during Somatic and Psychical Disorders
  • Methods of Behavioral Analysis in Neuroscience
Depressions during Somatic and Psychical Disorders
  • Depressions during Somatic and Psychical Disorders
  • 2003
Nauk
  • Nauk
  • 1998
...
...