Comparative Analysis of the Anxiolytic Effects of 3-Hydroxypyridine and Succinic Acid Derivatives

  title={Comparative Analysis of the Anxiolytic Effects of 3-Hydroxypyridine and Succinic Acid Derivatives},
  author={I A Volchegorskii and I. Yu. Miroshnichenko and L. M. Rassokhina and R. M. Faizullin and M. P. Malkin and Kateryna Pryakhina and Aleksandra V. Kalugina},
  journal={Bulletin of Experimental Biology and Medicine},
Threefold administration of 3-hydroxypyridine derivatives emoxipine and mexidol in optimal doses corresponding to the therapeutic dose range for humans produced an anxiolytic effect and stimulated risk behavior in the elevated plus maze test in rats. These effects were most pronounced after injection of 3-hydroxypyridine derivative emoxipine. Combination of 3-hydroxypyridine cation and succinate anion in the mexidol structure led to attenuation of the anxiolytic effect and less pronounced… 
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