Comparative Analysis of Methodologies for the Detection of Horizontally Transferred Genes: A Reassessment of First-Order Markov Models

@article{Cortez2005ComparativeAO,
  title={Comparative Analysis of Methodologies for the Detection of Horizontally Transferred Genes: A Reassessment of First-Order Markov Models},
  author={Diego Q. Cortez and Antonio Lazcano and Arturo Becerra},
  journal={In silico biology},
  year={2005},
  volume={5 5-6},
  pages={581-92}
}
With the advent of larger genome databases detection of horizontal gene transfer events has been transformed into an increasingly important issue. Here we present a simple theoretical analysis based on the in silico artificial addition of known foreign genes from different prokaryotic groups into the genome of Escherichia coli K12 MG1655. Using this dataset as a control, we have tested the efficiency of four methodologies commonly employed to detect HTG (Horizontally transferred genes), which… CONTINUE READING

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