Comparative Analysis of Measures of Viral Reservoirs in HIV-1 Eradication Studies

  title={Comparative Analysis of Measures of Viral Reservoirs in HIV-1 Eradication Studies},
  author={S Eriksson and Erin H. Graf and Viktor Dahl and Matthew C. Strain and Steven A Yukl and Elena S. Lysenko and Ronald J. Bosch and Jun F Lai and Stanley U. Chioma and Fatemeh Emad and Mohamed Abdel-Mohsen and Rebecca A. Hoh and Frederick M. Hecht and Peter Hunt and Ma Somsouk and Joseph Wong and Rowena Johnston and Robert F. Siliciano and Douglas D. Richman and Una T O'Doherty and Sarah K. Palmer and Steven G. Deeks and Janet D Siliciano},
  booktitle={PLoS pathogens},
HIV-1 reservoirs preclude virus eradication in patients receiving highly active antiretroviral therapy (HAART). The best characterized reservoir is a small, difficult-to-quantify pool of resting memory CD4(+) T cells carrying latent but replication-competent viral genomes. Because strategies targeting this latent reservoir are now being tested in clinical trials, well-validated high-throughput assays that quantify this reservoir are urgently needed. Here we compare eleven different approaches… CONTINUE READING
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