Comparative Analysis of Immune Repertoires between Bactrian Camel's Conventional and Heavy-Chain Antibodies

@inproceedings{Li2016ComparativeAO,
  title={Comparative Analysis of Immune Repertoires between Bactrian Camel's Conventional and Heavy-Chain Antibodies},
  author={Xinyang Li and Xiaobo Duan and Kai Yang and Wei Zhang and Changjiang Zhang and Longfei Fu and Zhe Ren and Changxi Wang and Jinghua Wu and Ruxue Lu and Yanrui Ye and Mengying He and Chao Nie and Naibo Yang and Jian Wang and Huanming Yang and Xiao Liu and Wen Tan},
  booktitle={PloS one},
  year={2016}
}
Compared to classical antibodies, camel heavy chain antibodies (HCAbs) are smaller in size due to lack of the light chain and the first constant domain of the heavy chain (CH1 region). The variable regions of HCAbs (VHHs) are more soluble and stable than that of conventional antibodies (VHs). Even with such simple structure, they are still functional in antigen binding. Although HCAbs have been extensively investigated over the past two decades, most efforts have been based upon low throughput… CONTINUE READING