Comparative Analysis of Four Oxidized Guanine Lesions from Reactions of DNA with Peroxynitrite, Singlet Oxygen, and γ-Radiation

@inproceedings{Cui2013ComparativeAO,
  title={Comparative Analysis of
Four Oxidized Guanine Lesions
from Reactions of DNA with Peroxynitrite, Singlet Oxygen, and γ-Radiation},
  author={Liang Cui and Wenjie Ye and Erin Prestwich and John S. Wishnok and Koli Taghizadeh and Peter C Dedon and Steven R Tannenbaum},
  booktitle={Chemical research in toxicology},
  year={2013}
}
Oxidative damage to DNA has many origins, including irradiation, inflammation, and oxidative stress, but the chemistries are not the same. The most oxidizable base in DNA is 2-deoxyguanosine (dG), and the primary oxidation products are 8-oxodG and 2-amino-imidazolone. The latter rapidly converts to 2,2-diamino-oxazolone (Ox), and 8-oxodG is further oxidized to spiroiminodihydantoin (Sp) and guanidinohydantoin (Gh). In this study, we have examined the dose-response relationship for the formation… CONTINUE READING