Comparative Analysis of Cytokinesis in Budding Yeast, Fission Yeast and Animal Cells

@article{Balasubramanian2004ComparativeAO,
  title={Comparative Analysis of Cytokinesis in Budding Yeast, Fission Yeast and Animal Cells},
  author={Mohan K. Balasubramanian and Erfei Bi and Michael Glotzer},
  journal={Current Biology},
  year={2004},
  volume={14},
  pages={R806-R818}
}

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References

SHOWING 1-10 OF 156 REFERENCES

Cytokinesis in fission yeast: A myosin pas de deux

What is known about the role of each myosin in cytokinesis is reviewed and some new information concerning their regulation and possible physical interaction is presented.

Septation and cytokinesis in fungi.

SEPH, a Cdc7p orthologue from Aspergillus nidulans, functions upstream of actin ring formation during cytokinesis

It is concluded that Aspergillus nidulans has components of a SIN–MEN pathway, one of which, SEPH, is required for early events during cytokinesis.

Movement of a cytokinesis factor cdc12p to the site of cell division

Isolation and characterization of new fission yeast cytokinesis mutants.

A phenotype that has not been described previously in cytokinesis mutants is characterized, namely the failure to reorganize actin patches to the medial region of the cell in preparation for septum formation.

Septins: A Highly Conserved Family of Membrane-Associated GTPases with Functions in Cell Division and Beyond

  • W. Trimble
  • Biology
    The Journal of Membrane Biology
  • 1999
More recent genetic and biochemical studies which hint at septins functions are focused on, and some speculation about their possible roles in cytokinesis and other cellular processes particularly in animal cells is provided.

A putative exchange factor for Rho1 GTPase is required for initiation of cytokinesis in Drosophila.

Pbl is identified as a RhoGEF specifically required for cytokinesis and linked through Rho1 activity to the reorganization of the actin cytoskeleton at the cleavage furrow.

Cytokinesis in fission yeast: a story of rings, rafts and walls.

Polarization of cell growth in yeast. I. Establishment and maintenance of polarity states.

The signaling pathways that regulate polarity are discussed, which are probably ancient and conserved mechanisms for regulating polarity and coordinate cytoskeletal organization with the cell cycle.
...