Comparative Analysis of CpG Islands in Four Fish Genomes

  title={Comparative Analysis of CpG Islands in Four Fish Genomes},
  author={Leng Han and Zhongming Zhao},
  journal={Comparative and Functional Genomics},
  pages={860 - 921}
There has been much interest in CpG islands (CGIs), clusters of CpG dinucleotides in GC-rich regions, because they are considered gene markers and involved in gene regulation. To date, there has been no genome-wide analysis of CGIs in the fish genome. We first evaluated the performance of three popular CGI identification algorithms in four fish genomes (tetraodon, stickleback, medaka, and zebrafish). Our results suggest that Takai and Jones' (2002) algorithm is most suitable for comparative… CONTINUE READING

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