Comparative 13C metabolic flux analysis of pyruvate dehydrogenase complex-deficient, L-valine-producing Corynebacterium glutamicum.

@article{Bartek2011Comparative1M,
  title={Comparative 13C metabolic flux analysis of pyruvate dehydrogenase complex-deficient, L-valine-producing Corynebacterium glutamicum.},
  author={Tobias Bartek and Bastian Blombach and Siegmund Lang and Bernhard J Eikmanns and Wolfgang Wiechert and Marco Oldiges and Katharina N{\"o}h and Stephan Noack},
  journal={Applied and environmental microbiology},
  year={2011},
  volume={77 18},
  pages={6644-52}
}
L-Valine can be formed successfully using C. glutamicum strains missing an active pyruvate dehydrogenase enzyme complex (PDHC). Wild-type C. glutamicum and four PDHC-deficient strains were compared by (13)C metabolic flux analysis, especially focusing on the split ratio between glycolysis and the pentose phosphate pathway (PPP). Compared to the wild type, showing a carbon flux of 69% ± 14% through the PPP, a strong increase in the PPP flux was observed in PDHC-deficient strains with a maximum… CONTINUE READING
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