Comparative, open, randomized trial of the efficacy and tolerance of slow- release 5-ASA suppositories once daily versus conventional 5-ASA suppositories twice daily in the treatment of active cryptogenic proctitis

@article{Marteau2000ComparativeOR,
  title={Comparative, open, randomized trial of the efficacy and tolerance of slow- release 5-ASA suppositories once daily versus conventional 5-ASA suppositories twice daily in the treatment of active cryptogenic proctitis},
  author={Philippe Marteau and Christian Florent},
  journal={American Journal of Gastroenterology},
  year={2000},
  volume={95},
  pages={166-170}
}
OBJECTIVE:The efficacy and tolerance of slow-release 5-ASA suppositories (Pentasa 1 g/day) were compared with those of conventional 5-ASA suppositories (Rowasa 0.5 g b.i.d.).METHODS:Two hundred and fifty-one (251) patients presenting with an exacerbation of cryptogenic proctitis were randomized. Clinical activity and rectal lesions were measured at days 1 and 14 (and at day 21 for patients not in remission at day 14), and each patient had to fill out a daily diary card (checklist).RESULTS… CONTINUE READING

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