Comparable frequency of BRCA1, BRCA2 and TP53 germline mutations in a multi-ethnic Asian cohort suggests TP53 screening should be offered together with BRCA1/2 screening to early-onset breast cancer patients

@inproceedings{Lee2011ComparableFO,
  title={Comparable frequency of BRCA1, BRCA2 and TP53 germline mutations in a multi-ethnic Asian cohort suggests TP53 screening should be offered together with BRCA1/2 screening to early-onset breast cancer patients},
  author={Daphne SC Lee and S Yoon and Lai-Meng Looi and Peter Choon Eng Kang and In Nee Kang and Kavitta Sivanandan and Hany Ariffin and Meow Keong Thong and Kin Fah Chin and Nur Aishah bt Mohd Taib and Cheng-Har Yip and Soo Hwang Teo},
  booktitle={Breast Cancer Research},
  year={2011}
}
Germline TP53 mutations cause an increased risk to early-onset breast cancer in Li-Fraumeni syndrome (LFS) families and the majority of carriers identified through breast cancer cohorts have LFS or Li-Fraumeni-like (LFL) features. However, in Asia and in many low resource settings, it is challenging to obtain accurate family history and we, therefore, sought to determine whether the presence of early-onset breast cancer is an appropriate selection criteria for germline TP53 testing. A total of… CONTINUE READING