Comparable efficacy and safety profiles of once-per-cycle pegfilgrastim and daily injection filgrastim in chemotherapy-induced neutropenia: a multicenter dose-finding study in women with breast cancer.

@article{Holmes2002ComparableEA,
  title={Comparable efficacy and safety profiles of once-per-cycle pegfilgrastim and daily injection filgrastim in chemotherapy-induced neutropenia: a multicenter dose-finding study in women with breast cancer.},
  author={Frankie Ann Holmes and Stephen E. Jones and Judy O'Shaughnessy and Suetislava Vukelja and Thomas George and Mihaela Savin and Drew Richards and J. Glaspy and Leah Meza and Gizella Cohen and Mandeep S Dhami and Daniel R. Budman and Jacqueline Hackett and Maryse Brassard and Bi bo Yang and Bertrand C. Liang},
  journal={Annals of oncology : official journal of the European Society for Medical Oncology},
  year={2002},
  volume={13 6},
  pages={903-9}
}
BACKGROUND Neutropenia is common in patients receiving myelotoxic chemotherapy. Pegfilgrastim, a sustained-duration filgrastim is a once-per-cycle therapy for prophylactic neutrophil support. PATIENTS AND METHODS Women, treated with four cycles of doxorubicin/docetaxel chemotherapy every 21 days, received pegfilgrastim or filgrastim 24 h after chemotherapy as a single subcutaneous injection per chemotherapy cycle (pegfilgrastim 30, 60 or 100 microg/kg) or daily subcutaneous injections… CONTINUE READING
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