Compaction properties of crystalline pharmaceutical ingredients according to the Walker model and nanomechanical attributes.

@article{Egart2014CompactionPO,
  title={Compaction properties of crystalline pharmaceutical ingredients according to the Walker model and nanomechanical attributes.},
  author={Mateja Egart and Ilija German Ili{\'c} and Biljana Jankovi{\'c} and Nor Zafirah Ab Lah and Stane Sr{\vc}i{\vc}},
  journal={International journal of pharmaceutics},
  year={2014},
  volume={472 1-2},
  pages={
          347-55
        }
}
This study investigates the extent to which single-crystal mechanical properties of selected active ingredients (famotidine, nifedipine, olanzapine, piroxicam) influence their bulk compressibility and compactibility. Nanomechanical attributes of oriented single crystals were determined with instrumented nanoindentation, and bulk deformational properties were assessed with the Walker and Heckel models as well as the elastic relaxation index. Good correlations were established between bulk and… CONTINUE READING
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