Comorbidity between temporal lobe epilepsy and depression: a [18F]MPPF PET study.

  title={Comorbidity between temporal lobe epilepsy and depression: a [18F]MPPF PET study.},
  author={Am{\'e}lie Lothe and Adrien Didelot and Alexander Hammers and Nicolas Costes and M. F. A. Saoud and Frank G. Gilliam and Philippe Ryvlin},
  journal={Brain : a journal of neurology},
  volume={131 Pt 10},
Brain and brainstem changes of serotoninergic 5-hydroxytryptophan (5-HT)(1A) receptor density have been reported in patients with major depressive disorder as well as in patients with temporal lobe epilepsy (TLE), using PET and the selective antagonist radiotracers [(11)C]WAY-100635 or [(18)F]FC-WAY. We used a distinct 5-HT(1A) antagonist, [(18)F]MPPF, whose binding potential depends on both receptor density and extracellular serotonin concentration, in 24 patients with drug-resistant TLE and… CONTINUE READING


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Effect of endogenous serotonin on the binding of the 5-hT1A PET ligand 18F-MPPF in the rat hippocampus: kinetic beta measurements combined with microdialysis

L Zimmer, G Mauger, +3 authors JF. Pujol
J Neurochem • 2002
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