Comorbidity: A network perspective

  title={Comorbidity: A network perspective},
  author={Ang{\'e}lique O. J. Cramer and Lourens J. Waldorp and H.L.J. van der Maas and Denny Borsboom},
  journal={Behavioral and Brain Sciences},
  pages={137 - 150}
Abstract The pivotal problem of comorbidity research lies in the psychometric foundation it rests on, that is, latent variable theory, in which a mental disorder is viewed as a latent variable that causes a constellation of symptoms. From this perspective, comorbidity is a (bi)directional relationship between multiple latent variables. We argue that such a latent variable perspective encounters serious problems in the study of comorbidity, and offer a radically different conceptualization in… Expand

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Complex dynamic systems of development
  • 2009
Diagnostic and Statistical Manual of Mental Disorders (DSM-IV)
This material was developed by Duke University, funded by the Department of Health and Human Services, Office of the National Coordinator for Health Information Technology under Award NumberExpand
The theoretical status
  • 2003
Two-group classification in latent trait theory: Scores with monotone likelihood ratio
This paper deals with two-group classification when a unidimensional latent trait,ϑ, is appropriate for explaining the data,X. It is shown that ifX has monotone likelihood ratio then optimalExpand
Neurologie Psychiatrie 68:1–11
  • 1979
Partial remission, residual symptoms, and relapse in depression
  • E. Paykel
  • Psychology, Medicine
  • Dialogues in clinical neuroscience
  • 2008
Residual symptoms are a strong indication for vigorous and longer than usual continuation of antidepressant treatment, in order to prevent relapse, and there is good evidence for the use of cognitive therapy as an adjunct. Expand
Affective Disorders 66:139–46
  • 2007
A tutorial on statistical methods for population association studies
  • D. Balding
  • Biology, Medicine
  • Nature Reviews Genetics
  • 2006
An overview of statistical approaches to population association studies, including preliminary analyses (Hardy–Weinberg equilibrium testing, inference of phase and missing data, and SNP tagging), and single-SNP and multipoint tests for association. Expand
Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication.
Lifetime prevalence estimates are higher in recent cohorts than in earlier cohorts and have fairly stable intercohort differences across the life course that vary in substantively plausible ways among sociodemographic subgroups. Expand