Comorbidities of asthma: current knowledge and future research needs

@article{Cazzola2013ComorbiditiesOA,
  title={Comorbidities of asthma: current knowledge and future research needs},
  author={M. Cazzola and A. Segreti and L. Calzetta and P. Rogliani},
  journal={Current Opinion in Pulmonary Medicine},
  year={2013},
  volume={19},
  pages={36–41}
}
Purpose of review Asthma is often associated with different comorbidities, mainly gastro-oesophageal reflux disease and allergic rhinitis, but also obesity, depression, diabetes mellitus and cardiovascular disease, which may affect its clinical intensity and severity. The prevalence of these comorbidities varies tremendously between studies. Nevertheless, it imposes a significant reflection on the need to explore the phenomenon in depth. Recent findings Both clinical and basic studies have… Expand
Emerging Comorbidities in Adult Asthma: Risks, Clinical Associations, and Mechanisms
TLDR
The emerging comorbid conditions to asthma such as obesity, metabolic syndrome, diabetes mellitus type 2 (DM2), and cardiac and psychiatric diseases are reviewed and their role as risk factors for incident asthma and whether they affect clinical asthma are evaluated. Expand
The impact of comorbidities on severe asthma.
TLDR
The identification of comorbidities via multidimensional approach is needed to initiate appropriate multidisciplinary management of patients with severe asthma. Expand
Asthma, GERD and Obesity: Triangle of Inflammation
TLDR
A better understanding of mechanisms by which obesity and GERD lead to inflammation in airways and increase the risk of asthma may provide insight towards targeted treatment approach of these patients. Expand
Asthma and metabolic syndrome: Current knowledge and future perspectives.
TLDR
The purpose of this review is to describe the current knowledge about the possible link between metabolic syndrome and asthma, and explore potential application for future studies and strategic approaches. Expand
Body Mass Index and Comorbidities in Adult Severe Asthmatics
TLDR
It is found that the optimal state of asthma control is lower in obese than in overweight and normal weight severe asthmatics, and BMI represents per se a factor for the deterioration in disease control in severe asthma. Expand
Asthma therapeutic management : a pharmacoepidemiological approach
TLDR
It is shown that the controller-to-total asthma medication ratio is also relevant in the elderly and identified specific patterns of fluctuations of the ratio significantly associated with the subsequent risk for poor asthma-related outcomes. Expand
Impact of Obesity on Adipokines, Inflammatory Cytokines and Clinical Symptoms Control in Asthmatic Subjects
TLDR
The aim of this study was to measure the relationship between Adipokines, inflammatory cytokines and clinical symptoms in obese asthmatic Saudi patients. Expand
Bronchodilators in subjects with asthma-related comorbidities.
TLDR
A narrative review examines the potential effects of bronchodilators on comorbidities of asthma and finds no overall description of their impact on asthma, regardless of whether favourable or negative. Expand
Comorbidities in asthma and chronic obstructive pulmonary disease among adult inhabitants of Silesian Voivodeship, Poland
TLDR
The aim of the study was to assess the prevalence of comorbidities of asthma and COPD and recognize the frequency of ACOS in the Silesian Voivodeship, along with the total costs of hospitalization refunded by the National Health Fund (NHF). Expand
IgE-Mediated Multimorbidities in Allergic Asthma and the Potential for Omalizumab Therapy.
TLDR
Omalizumab is a recombinant humanized monoclonal antibody against IgE and has been in use to treat allergic asthma for more than a decade and is comprehensively reviewed in this review. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 66 REFERENCES
Asthma and obesity: A known association but unknown mechanism
TLDR
Obesity results in important changes to the mechanical properties of the respiratory system, and these obesity‐related factors appear to exert an additive effect to the asthma‐related changes seen in the airways. Expand
Influence of comorbid conditions on asthma
  • L. Boulet
  • Medicine
  • European Respiratory Journal
  • 2009
TLDR
A systematic evaluation and an appropriate treatment of asthma-associated comorbid conditions should be part of asthma management, particularly for severe disease. Expand
Asthma-related comorbidities
TLDR
The most frequently reported asthma comorbid conditions include rhinitis, sinusitis, gastroesophageal reflux disease, obstructive sleep apnea, hormonal disorders and psychopathologies, which may share a common pathophysiological mechanism with asthma. Expand
Asthma and comorbid medical illness
TLDR
The results indicate that asthma is weakly associated with several comorbidities, whereas its association with allergic rhinitis or GORD is stronger. Expand
Obesity and asthma: co-morbidity or causal relationship?
TLDR
In animal models, there is an increasing amount of evidence for the role of adipokines derived from fat tissue in the relationship between obesity and asthma, but the data are conflicting in humans. Expand
Obesity, metabolic dysregulation and oxidative stress in asthma.
TLDR
The current evidence suggests that while oxidative stress is important in asthma, it does not fully explain the characteristics associated with this unique phenotype and the possible mechanisms mediating the effects of obesity on asthma. Expand
Asthma is associated with cardiovascular disease in a representative population sample.
TLDR
In a representative population sample, asthma was associated with CVD/stroke after adjustment for traditional risk factors and lung function and no significant effect modification by BMI was observed in relation to CVD, or diabetes. Expand
Systemic inflammation in chronic obstructive pulmonary disease and asthma: relation with comorbidities.
TLDR
Research should elucidate the complex relationship between obstructive lung disease, coexisting conditions, systemic inflammation accompanying these different conditions, and the causative role of systemic inflammation for comorbidities in COPD and asthma. Expand
United airways concept: what does it teach us about systemic inflammation in airways disease?
  • G. Braunstahl
  • Medicine
  • Proceedings of the American Thoracic Society
  • 2009
TLDR
Nasal therapy in allergic rhinitis patients with asthma has a beneficial effect on asthma symptoms, bronchial hyperresponsiveness, and airway inflammation, and it reduces the risk of asthma exacerbations. Expand
Systemic and local inflammation in asthma and chronic obstructive pulmonary disease: is there a connection?
TLDR
Adipose tissue-mediated inflammation is discussed as a connecting link of systemic inflammation in asthma and COPD, and the spill-over hypothesis is challenged. Expand
...
1
2
3
4
5
...