Comorbidities of asthma: current knowledge and future research needs

  title={Comorbidities of asthma: current knowledge and future research needs},
  author={Mario Cazzola and A. Mark Segreti and Luigino Calzetta and Paola Rogliani},
  journal={Current Opinion in Pulmonary Medicine},
Purpose of review Asthma is often associated with different comorbidities, mainly gastro-oesophageal reflux disease and allergic rhinitis, but also obesity, depression, diabetes mellitus and cardiovascular disease, which may affect its clinical intensity and severity. The prevalence of these comorbidities varies tremendously between studies. Nevertheless, it imposes a significant reflection on the need to explore the phenomenon in depth. Recent findings Both clinical and basic studies have… 

Emerging Comorbidities in Adult Asthma: Risks, Clinical Associations, and Mechanisms

The emerging comorbid conditions to asthma such as obesity, metabolic syndrome, diabetes mellitus type 2 (DM2), and cardiac and psychiatric diseases are reviewed and their role as risk factors for incident asthma and whether they affect clinical asthma are evaluated.

The impact of comorbidities on severe asthma.

The identification of comorbidities via multidimensional approach is needed to initiate appropriate multidisciplinary management of patients with severe asthma.

Asthma, GERD and Obesity: Triangle of Inflammation

A better understanding of mechanisms by which obesity and GERD lead to inflammation in airways and increase the risk of asthma may provide insight towards targeted treatment approach of these patients.

Body Mass Index and Comorbidities in Adult Severe Asthmatics

It is found that the optimal state of asthma control is lower in obese than in overweight and normal weight severe asthmatics, and BMI represents per se a factor for the deterioration in disease control in severe asthma.

Asthma therapeutic management : a pharmacoepidemiological approach

It is shown that the controller-to-total asthma medication ratio is also relevant in the elderly and identified specific patterns of fluctuations of the ratio significantly associated with the subsequent risk for poor asthma-related outcomes.

Impact of Obesity on Adipokines, Inflammatory Cytokines and Clinical Symptoms Control in Asthmatic Subjects

The aim of this study was to measure the relationship between Adipokines, inflammatory cytokines and clinical symptoms in obese asthmatic Saudi patients.

IgE-Mediated Multimorbidities in Allergic Asthma and the Potential for Omalizumab Therapy.

Monitoring asthma in childhood: management-related issues

The evidence indicates that it is important to discuss adherence to treatment in a non-confrontational way at every clinic visit, and take into account a patient's illness and medication beliefs, as agreed by the European Respiratory Society Task Force on Monitoring Asthma in Childhood.



Asthma and obesity: A known association but unknown mechanism

Obesity results in important changes to the mechanical properties of the respiratory system, and these obesity‐related factors appear to exert an additive effect to the asthma‐related changes seen in the airways.

Influence of comorbid conditions on asthma

  • L. Boulet
  • Medicine
    European Respiratory Journal
  • 2009
A systematic evaluation and an appropriate treatment of asthma-associated comorbid conditions should be part of asthma management, particularly for severe disease.

Asthma-related comorbidities

The most frequently reported asthma comorbid conditions include rhinitis, sinusitis, gastroesophageal reflux disease, obstructive sleep apnea, hormonal disorders and psychopathologies, which may share a common pathophysiological mechanism with asthma.

Asthma and comorbid medical illness

The results indicate that asthma is weakly associated with several comorbidities, whereas its association with allergic rhinitis or GORD is stronger.

Obesity and asthma: co-morbidity or causal relationship?

In animal models, there is an increasing amount of evidence for the role of adipokines derived from fat tissue in the relationship between obesity and asthma, but the data are conflicting in humans.

Obesity, metabolic dysregulation and oxidative stress in asthma.

Asthma is associated with cardiovascular disease in a representative population sample.

Systemic inflammation in chronic obstructive pulmonary disease and asthma: relation with comorbidities.

Research should elucidate the complex relationship between obstructive lung disease, coexisting conditions, systemic inflammation accompanying these different conditions, and the causative role of systemic inflammation for comorbidities in COPD and asthma.

Systemic and local inflammation in asthma and chronic obstructive pulmonary disease: is there a connection?

Adipose tissue-mediated inflammation is discussed as a connecting link of systemic inflammation in asthma and COPD, and the spill-over hypothesis is challenged.

Evaluation of Glucose Tolerance Status in Patients with Asthma Bronchiale

The results suggest that disturbance of the glucose metabolism caused by inflammation-induced insulin resistance may occur in asthmatic patients and that this phenomenon may increase the risk of diabetes mellitus in these individuals.