Community behavior and spatial regulation within a bacterial microcolony in deep tissue sites serves to protect against host attack.

@article{Davis2015CommunityBA,
  title={Community behavior and spatial regulation within a bacterial microcolony in deep tissue sites serves to protect against host attack.},
  author={Kimberly M. Davis and Sina Mohammadi and Ralph R Isberg},
  journal={Cell host & microbe},
  year={2015},
  volume={17 1},
  pages={21-31}
}
Bacterial pathogens express virulence-specific transcriptional programs that allow tissue colonization. Although phenotypic variation has been noted in the context of antibiotic exposure, no direct evidence exists for heterogeneity in virulence-specific transcriptional programs within tissues. In a mouse model of Yersinia pseudotuberculosis infection, we show that at least three subpopulations of bacteria develop within a single tissue site in response to distinct host signals. Bacteria growing… CONTINUE READING

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