Community-based trial of a triple-combination agent for the treatment of facial melasma.

@article{Grimes2006CommunitybasedTO,
  title={Community-based trial of a triple-combination agent for the treatment of facial melasma.},
  author={Pearl E. Grimes and A Paul Kelly and Helen Mary Torok and Isaac Willis},
  journal={Cutis},
  year={2006},
  volume={77 3},
  pages={177-84}
}
Melasma is a common hyperpigmentation disorder that is frequently recalcitrant to treatment. An 8-week, multicenter, open-label, community-based study evaluated a new therapeutic approach that combines tretinoin 0.05%, hydroquinone 4.0%, and fluocinolone acetonide 0.01% (RA+HQ+FA) in a hydrophilic cream formulation. The trial enrolled 1290 patients of diverse races/ethnicities with a full range of Fitzpatrick skin types (I through VI). The mean Melasma Area and Severity Index (MASI) decreased… CONTINUE READING

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