Community‐Based Study of Lennox‐Gastaut Syndrome

@article{Heiskala1997CommunityBasedSO,
  title={Community‐Based Study of Lennox‐Gastaut Syndrome},
  author={Hannu J Heiskala},
  journal={Epilepsia},
  year={1997},
  volume={38}
}
Summary: Purpose: Before 1986, the spectrum of childhood epilepsies, including Lennox‐Gastaut syndrome (LGS) and Doose syndrome (DS), known collectively as “epilepsia myoclonica astatica”, was believed to represent a single disease. More recently, some investigators have considered these syndromes to be parts of a continuum. To clarify these theories, neurobiologic factors of the syndromes were studied to determine which qualities were shared and which were unique. 
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  • 2020
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References

SHOWING 1-10 OF 42 REFERENCES
The Lennox-Gastaut syndrome and its frontiers.
TLDR
This severe and almost intractable seizure disorder must be distinguished from a variety of other epileptic conditions which may electroencephalographically mimic the Lennox-Gastaut syndrome. Expand
West syndrome and Lennox-Gastaut syndrome: a survey of natural history.
TLDR
A nationwide survey in Japan was performed to elucidate the natural history of these two syndromes, the West syndrome and the Lennox-Gastaut syndrome. Expand
Morphological and Biochemical Analysis of a Brain Biopsy in a Case of Idiopathic Lennox‐Gastaut Syndrome
TLDR
While the outer layers of the cortex were morphologically normal, the neurons of the inner layers showed a poor dendritic arborization and a diminished number of spines, which can be considered the basis of excessive excitability which in turn may further impair brain development. Expand
The Lennox-Gastaut syndrome.
In Lennox-Gastaut syndrome, epilepsy begins in early childhood, usually between ages 3 and 5. The most common seizure type is tonic seizures, which cause the muscles to stiffen (contract)Expand
A Dysbalanced Immune System in Cryptogenic Lennox‐Gastaut Syndrome
In children with cryptogenic Lennox‐Gastaut syndrome we found a functionally impaired humoral immune response to a primary antigen (haemocyanin), despite signs of a triggered immune system consistingExpand
[Lennox-Gastaut syndrome].
TLDR
There is still no successful treatment for these seizures and progressive mental deterioration occurs even when using the newer anti-epileptic drugs, so electrical stimulation of the vagus nerve seems a promising possibility. Expand
Classifying epileptic syndromes: problems and a neurobiologic solution.
TLDR
When syndromic classification is not possible, it is often more useful to consider genetic, clinical, electroencephalographic, neuropsychologic, radiologic, and other laboratory factors in characterizing the epileptic condition and selecting the optimal treatment. Expand
Prognosis of Childhood Seizure Disorders: Present and Future
TLDR
The realization emerged that, ultimately, prognosis depends on causation, which, in turn, determines whether a condition is self‐limited or progressive, more important than either mode or alacrity of therapeutic intervention. Expand
Predisposing and Causative Factors in Childhood Epilepsy
TLDR
Examining the role of known factors and especially of prenatal and perinatal factors in contributing to nonfebrile seizure disorders of early childhood found maldevelopment, rather than damage at birth to an initially intact nervous system, appeared to be the more common mechanism. Expand
Serologic HLA typing in cryptogenic Lennox-Gastaut syndrome.
TLDR
Serologic HLA typing was performed on patients with cryptogenic Lennox-Gastaut syndrome and compared to a normal control group of 1661 Caucasians and no significant differences existed in the frequencies of HLA-A, B, and C antigens. Expand
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