Communication between the N and C termini is required for copper-stimulated Ser/Thr phosphorylation of Cu(I)-ATPase (ATP7B).

Abstract

The Wilson disease protein ATP7B exhibits copper-dependent trafficking. In high copper, ATP7B exits the trans-Golgi network and moves to the apical domain of hepatocytes where it facilitates elimination of excess copper through the bile. Copper levels also affect ATP7B phosphorylation. ATP7B is basally phosphorylated in low copper and becomes more… (More)
DOI: 10.1074/jbc.M114.627414

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@article{Braiterman2015CommunicationBT, title={Communication between the N and C termini is required for copper-stimulated Ser/Thr phosphorylation of Cu(I)-ATPase (ATP7B).}, author={Lelita T. Braiterman and Arnab Gupta and Raghothama Chaerkady and Robert N Cole and Ann L. Hubbard}, journal={The Journal of biological chemistry}, year={2015}, volume={290 14}, pages={8803-19} }