Communication between pathogenic T cells and myeloid cells in neuroinflammatory disease.

@article{Codarri2013CommunicationBP,
  title={Communication between pathogenic T cells and myeloid cells in neuroinflammatory disease.},
  author={Laura Codarri and Melanie Greter and Burkhard Becher},
  journal={Trends in immunology},
  year={2013},
  volume={34 3},
  pages={114-9}
}
Clinical and experimental data suggest that T helper (TH) cells are involved in the pathogenicity of experimental autoimmune encephalomyelitis (EAE) and multiple sclerosis (MS), but it is unlikely that they are directly responsible for the observed demyelination and axonal loss. Instead, the cell population that targets the destruction of oligodendrocytes and axons, and the mechanism exploited by central nervous system (CNS)-invading encephalitogenic TH cells to instruct these cells to mediate… CONTINUE READING
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