Commonly used surfactant, Tween 80, improves absorption of P-glycoprotein substrate, digoxin, in rats.

@article{Zhang2003CommonlyUS,
  title={Commonly used surfactant, Tween 80, improves absorption of P-glycoprotein substrate, digoxin, in rats.},
  author={Hongjian Zhang and Ming Yao and Richard A. Davis Charles H. May Kelly I. Morrison and Saeho Chong},
  journal={Archives of pharmacal research},
  year={2003},
  volume={26 9},
  pages={768-72}
}
Tween 80 (Polysorbate 80) is a hydrophilic nonionic surfactant commonly used as an ingredient in dosing vehicles for pre-clinical in vivo studies (e.g., pharmacokinetic studies, etc.). Tween 80 increased apical to basolateral permeability of digoxin in Caco-2 cells suggesting that Tween 80 is an in vitro inhibitor of P-gp. The overall objective of the present study was to investigate whether an inhibition of P-gp by Tween 80 can potentially influence in vivo absorption of P-gp substrates by… CONTINUE READING

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