Commonly studied polymorphisms in inflammatory cytokine genes show only minor effects on mortality and related risk factors in nonagenarians.

@article{Dato2010CommonlySP,
  title={Commonly studied polymorphisms in inflammatory cytokine genes show only minor effects on mortality and related risk factors in nonagenarians.},
  author={Serena Dato and Karen Su{\'a}rez Krabbe and Mikael Thinggaard and Bente Klarlund Pedersen and Kaare Christensen and Helle Bruunsgaard and Lene Christiansen},
  journal={The journals of gerontology. Series A, Biological sciences and medical sciences},
  year={2010},
  volume={65 3},
  pages={225-35}
}
Systemic low-grade inflammation is consistently associated with functional status, cognitive functioning, multimorbidity, and survival in oldest olds. If inflammation is either a cause or a consequence of age-related pathology, genetic determinants of late-life survival can reside in cytokine genes polymorphisms, regulating inflammatory responses. The aim of this study was to test associations between commonly studied polymorphisms in interleukin (IL)6, IL10, IL15, and IL18, and tumor necrosis… CONTINUE READING

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Genetic Data Analysis II

  • BS Weir
  • Sunderland, MA: Sinauer Associates;
  • 1996
Highly Influential
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