Commonly prescribed β-lactam antibiotics induce C. trachomatis persistence/stress in culture at physiologically relevant concentrations

@inproceedings{Kintner2014CommonlyP,
  title={Commonly prescribed β-lactam antibiotics induce C. trachomatis persistence/stress in culture at physiologically relevant concentrations},
  author={Jennifer Kintner and Dawn R. Lajoie and Jennifer Vanover Hall and Judy D. Whittimore and Robert Vincent Schoborg},
  booktitle={Front. Cell. Infect. Microbiol.},
  year={2014}
}
Chlamydia trachomatis, the most common bacterial sexually transmitted disease agent worldwide, enters a viable, non-dividing and non-infectious state (historically termed persistence and more recently referred to as the chlamydial stress response) when exposed to penicillin G in culture. Notably, penicillin G-exposed chlamydiae can reenter the normal developmental cycle upon drug removal and are resistant to azithromycin-mediated killing. Because penicillin G is less frequently prescribed than… CONTINUE READING

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  • 2018
VIEW 8 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

References

Publications referenced by this paper.
SHOWING 1-10 OF 66 REFERENCES

In vitro evaluation of activities

L. E. 2105AJPH.47.6.701 Welsh, C. A. Gaydos, T. C. Quinn
  • 1992
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Promoting resistance by the emission of antibiotics from hospitals and households into effluent.

  • Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
  • 2003
VIEW 8 EXCERPTS
HIGHLY INFLUENTIAL

Presentation of clin

S. Alexander, P. J. Horner, C. A. Ison
  • 2013