Commonly occurring loss and mutation of the MXI1 gene in prostate cancer.

  title={Commonly occurring loss and mutation of the MXI1 gene in prostate cancer.},
  author={Edward V. Prochownik and L Eagle Grove and Dale Deubler and Xue Liang Zhu and Robert A. Stephenson and L Ralph Rohr and Xiang-ping Yin and Arthur R. Brothman},
  journal={Genes, chromosomes & cancer},
  volume={22 4},
One of the most common chromosomal abnormalities in prostate cancer involves loss of 10q22-qter. Rarely, a smaller deletion, involving 10q24-q25, has been observed, suggesting the presence of a tumor suppressor gene at this site. We previously demonstrated that the MXI1 gene maps to 10q24-q25 and is mutated in some tumors with cytogenetically detectable deletions of this locus. MXI1 encodes a basic-helix-loop-helix protein that suppresses the transcriptional activity of the MYC oncoprotein by… CONTINUE READING


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