Common vs. rare allele hypotheses for complex diseases.

  title={Common vs. rare allele hypotheses for complex diseases.},
  author={Nicholas J. Schork and Sarah S. Murray and Kelly Frazer and Eric J. Topol},
  journal={Current opinion in genetics & development},
  volume={19 3},
There has been growing debate over the nature of the genetic contribution to individual susceptibility to common complex diseases such as diabetes, osteoporosis, and cancer. The 'Common Disease, Common Variant (CDCV)' hypothesis argues that genetic variations with appreciable frequency in the population at large, but relatively low 'penetrance' (or the probability that a carrier of the relevant variants will express the disease), are the major contributors to genetic susceptibility to common… CONTINUE READING
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