Common variations in estrogen-related genes are associated with severe large-joint osteoarthritis: a multicenter genetic and functional study.

@article{Riancho2010CommonVI,
  title={Common variations in estrogen-related genes are associated with severe large-joint osteoarthritis: a multicenter genetic and functional study.},
  author={Jos{\'e} A Riancho and Carmen Garc{\'i}a-Ibarbia and Athanasia Gravani and Emma V A Raine and Cristina Rodriguez-Fontenla and Angel Soto-Hermida and Ignacio Rego-P{\'e}rez and Alyson Dodd and Juan J G{\'o}mez-Reino and Mar{\'i}a Teresa Zarrabeitia and Carlos Mario Escobar Garc{\'e}s and Aoife Carr and Fernanda Blanco and Adriana Gonz{\'a}lez and John Loughlin},
  journal={Osteoarthritis and cartilage},
  year={2010},
  volume={18 7},
  pages={
          927-33
        }
}
OBJECTIVE Several lines of evidence suggest that estrogens influence the development of osteoarthritis (OA). The aim of this study was to explore the association of two common polymorphisms within the aromatase (CYP19A1) and estrogen receptor (ER) alpha (ESR1) genes with severe OA of the lower limbs. METHODS The rs1062033 (CYP19A1) and rs2234693 (ESR1) single nucleotide polymorphisms were genotyped in 5528 individuals (3147 patients with severe hip or knee OA, and 2381 controls) from four… CONTINUE READING
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