Common variation in three genes, including a noncoding variant in CFH, strongly influences risk of age-related macular degeneration

@article{Maller2006CommonVI,
  title={Common variation in three genes, including a noncoding variant in CFH, strongly influences risk of age-related macular degeneration},
  author={Julian B. Maller and Sarah George and Shaun M Purcell and Jesen A. Fagerness and David M Altshuler and Mark J. Daly and Johanna M. Seddon},
  journal={Nature Genetics},
  year={2006},
  volume={38},
  pages={1055-1059}
}
Age-related macular degeneration (AMD) is a common, late-onset disease with seemingly typical complexity: recurrence ratios for siblings of an affected individual are three- to sixfold higher than in the general population, and family-based analysis has resulted in only modestly significant evidence for linkage. In a case-control study drawn from a US-based population of European descent, we have identified a previously unrecognized common, noncoding variant in CFH, the gene encoding complement… Expand
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