Common variation in the C-terminal region of the fibrinogen beta-chain: effects on fibrin structure, fibrinolysis and clot rigidity.

@article{Ajjan2008CommonVI,
  title={Common variation in the C-terminal region of the fibrinogen beta-chain: effects on fibrin structure, fibrinolysis and clot rigidity.},
  author={Ramzi A. Ajjan and Bernard C B Lim and Kristina F. Standeven and Robert Harrand and Sarah Dolling and Fladia Phoenix and Richard Greaves and Radwa H Abou-Saleh and Simon D A Connell and D Alastair M Smith and John W. Weisel and Peter J. Grant and Robert A S Ari{\"e}ns},
  journal={Blood},
  year={2008},
  volume={111 2},
  pages={643-50}
}
Fibrinogen BbetaArg448Lys is a common polymorphism, positioned within the carboxyl terminus of the Bbeta-chain of the molecule. Studies suggest that it is associated with severity of coronary artery disease and development of stroke. The effects of the amino acid substitution on clot structure remains controversial, and the aim of this study was to investigate the effect(s) of this polymorphism on fibrin clot structure using recombinant techniques. Permeation, turbidity, and scanning electron… CONTINUE READING
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