Common variation in GRB-associated Binding Protein 2 (GAB2) and increased risk for Alzheimer dementia.

@article{Sleegers2009CommonVI,
  title={Common variation in GRB-associated Binding Protein 2 (GAB2) and increased risk for Alzheimer dementia.},
  author={Kristel Sleegers and Karolien Bettens and Nathalie Brouwers and Sebastiaan Engelborghs and Helen Van Miegroet and Peter Paul De Deyn and Christine van Broeckhoven},
  journal={Human mutation},
  year={2009},
  volume={30 2},
  pages={E338-44}
}
GRB-associated binding protein 2 (GAB2) was recently reported to be a modifier of late-onset Alzheimer dementia (AD) risk in carriers of the APOE epsilon4 allele in a genome-wide association analysis. We aimed to investigate this association in a well-characterized Belgian late-onset AD patient/control group: 528 Belgian AD patients (mean onset age 79.0+/-5.2 years, 70.2% females) and 601 ethnically matched control individuals (mean age 61.9+/-15.3 years, 57.1% females) were genotyped for 10… CONTINUE READING