Common variants of the G protein-coupled receptor type 4 are associated with human essential hypertension and predict the blood pressure response to angiotensin receptor blockade

@article{Sanada2016CommonVO,
  title={Common variants of the G protein-coupled receptor type 4 are associated with human essential hypertension and predict the blood pressure response to angiotensin receptor blockade},
  author={Hisakazu Sanada and Masayasu Yoneda and Junichi Yatabe and Scott M. Williams and Jackie Bartlett and Marquitta J White and Lindsay N. Gordon and Robin A. Felder and Gilbert M. Eisner and I Armando and Pedro A. Jos{\'e}},
  journal={The Pharmacogenomics Journal},
  year={2016},
  volume={16},
  pages={3-9}
}
Non-synonymous GRK4 variants, R65L, A142V and A486V, are associated with essential hypertension in diverse populations. This study replicated the association of GRK4 variants, including GRK4142V, with human essential hypertension in a Japanese population (n=588; hypertensive, n=486 normotensive controls) and determined whether the presence of GRK4 variants predicted the blood pressure (BP) response to angiotensin receptor blockers (ARBs) in patients with essential hypertension. We analyzed 829… CONTINUE READING
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