Common variants of OPA1 conferring genetic susceptibility to leprosy in Han Chinese from Southwest China.

@article{Xiang2015CommonVO,
  title={Common variants of OPA1 conferring genetic susceptibility to leprosy in Han Chinese from Southwest China.},
  author={Yang-Lin Xiang and Deng-Feng Zhang and Dong Wang and Yu-ye Li and Yong-Gang Yao},
  journal={Journal of dermatological science},
  year={2015},
  volume={80 2},
  pages={
          133-41
        }
}
BACKGROUND Leprosy is an ancient chronic infection caused by Mycobacterium leprae. Onset of leprosy was highly affected by host nutritional condition and energy production, (partially) due to genomic loss and parasitic life style of M. leprae. The optic atrophy 1 (OPA1) gene plays an essential role in mitochondria, which function in cellular energy supply and innate immunity. OBJECTIVE To investigate the potential involvement of OPA1 in leprosy. METHODS We analyzed 7 common genetic variants… CONTINUE READING