Common variants near TARDBP and EGR2 are associated with susceptibility to Ewing sarcoma

@article{PostelVinay2012CommonVN,
  title={Common variants near TARDBP and EGR2 are associated with susceptibility to Ewing sarcoma},
  author={Sophie Postel-Vinay and Am{\'e}lie S. V{\'e}ron and Franck Tirode and Gaelle Pierron and St{\'e}phanie Reynaud and Heinrich Kovar and Odile Oberlin and Eve Lapouble and Stelly Ballet and Carlo Lucchesi and Udo Kontny and Anna Gonz{\'a}lez-Neira and Piero Picci and Javier Alonso and Ana Pati{\~n}o-Garc{\'i}a and Brigitte Bressac-de Paillerets and Karine Laud and Christian Dina and Philippe Froguel and Francoise Clavel-Chapelon and François Doz and Jean Michon and Stephen J. Chanock and Gilles D. Thomas and David G. Cox and Olivier Delattre},
  journal={Nature Genetics},
  year={2012},
  volume={44},
  pages={323-327}
}
Ewing sarcoma, a pediatric tumor characterized by EWSR1-ETS fusions, is predominantly observed in populations of European ancestry. We performed a genome-wide association study (GWAS) of 401 French individuals with Ewing sarcoma, 684 unaffected French individuals and 3,668 unaffected individuals of European descent and living in the United States. We identified candidate risk loci at 1p36.22, 10q21 and 15q15. We replicated these loci in two independent sets of cases and controls. Joint analysis… Expand
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