Common variants near MC4R are associated with fat mass, weight and risk of obesity

@article{Loos2008CommonVN,
  title={Common variants near MC4R are associated with fat mass, weight and risk of obesity},
  author={R. Loos and C. Lindgren and Shengxu Li and E. Wheeler and J. Zhao and I. Prokopenko and M. Inouye and R. Freathy and A. Attwood and J. Beckmann and S. Berndt and S. Bergmann and A. Bennett and S. Bingham and M. Bochud and Morris J. Brown and S. Cauchi and J. Connell and C. Cooper and George Davey Smith and I. Day and C. Dina and S. De and E. Dermitzakis and A. Doney and K. Elliott and P. Elliott and David M. Evans and I. Farooqi and P. Froguel and J. Ghori and C. Groves and R. Gwilliam and D. Hadley and A. Hall and A. Hattersley and J. Hebebrand and I. Heid and B. Herrera and A. Hinney and S. Hunt and M. Jarvelin and T. Johnson and J. Jolley and F. Karpe and A. Keniry and K. Khaw and R. Luben and M. Mangino and J. Marchini and W. McArdle and R. McGinnis and D. Meyre and P. Munroe and A. Morris and A. Ness and M. Neville and A. Nica and K. Ong and S. O’Rahilly and K. Owen and C. Palmer and Konstantinos Papadakis and S. Potter and A. Pouta and L. Qi and J. Randall and N. W. Rayner and S. Ring and M. Sandhu and A. Scherag and M. Sims and K. Song and N. Soranzo and E. Speliotes and H. Syddall and S. Teichmann and N. Timpson and J. Tobias and M. Uda and C. Vogel and C. Wallace and D. Waterworth and M. Weedon and C. Willer and Vicki L. Wraight and Xin Yuan and E. Zeggini and J. Hirschhorn and D. Strachan and W. Ouwehand and M. Caulfield and N. Samani and T. Frayling and P. Vollenweider and G. Waeber and V. Mooser and P. Deloukas and M. McCarthy and N. Wareham and I. Barroso},
  journal={Nature Genetics},
  year={2008},
  volume={40},
  pages={768-775}
}
To identify common variants influencing body mass index (BMI), we analyzed genome-wide association data from 16,876 individuals of European descent. After previously reported variants in FTO, the strongest association signal (rs17782313, P = 2.9 × 10−6) mapped 188 kb downstream of MC4R (melanocortin-4 receptor), mutations of which are the leading cause of monogenic severe childhood-onset obesity. We confirmed the BMI association in 60,352 adults (per-allele effect = 0.05 Z-score units; P = 2.8… Expand

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ConditionsHigh Risk MC4R Genotype, Low Risk MC4R Genotype, One Week or Less Antipsychotic Lifetime Exposure
InterventionDrug
Combined effects of MC4R and FTO common genetic variants on obesity in European general populations
Replication of genetic effects of MC4R polymorphisms on body mass index in a Korean population
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Melanocortin-4 receptor gene variant I103 is negatively associated with obesity.
Variation in FTO contributes to childhood obesity and severe adult obesity
Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency.
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