Common variants in the region around Osterix are associated with bone mineral density and growth in childhood

@article{Timpson2009CommonVI,
  title={Common variants in the region around Osterix are associated with bone mineral density and growth in childhood},
  author={Nicholas J. Timpson and Jon H. Tobias and J Brent Richards and Nicole Soranzo and Emma L. Duncan and Anne-Marie Sims and Pamela Whittaker and Vasudev Kumanduri and Guangju Zhai and Beate Glaser and John Eisman and Graeme Jones and Geoffrey Charles Nicholson and Richard Prince and E. R. BernsteinJeffrey I. Seeman and Tim D. Spector and Matthew A Brown and L. Peltonen and George Davey Smith and Panagiotis Deloukas and David M. Evans},
  journal={Human Molecular Genetics},
  year={2009},
  volume={18},
  pages={1510 - 1517}
}
Peak bone mass achieved in adolescence is a determinant of bone mass in later life. In order to identify genetic variants affecting bone mineral density (BMD), we performed a genome-wide association study of BMD and related traits in 1518 children from the Avon Longitudinal Study of Parents and Children (ALSPAC). We compared results with a scan of 134 adults with high or low hip BMD. We identified associations with BMD in an area of chromosome 12 containing the Osterix (SP7) locus, a… CONTINUE READING