Common variants in the TCF7L2 gene help to differentiate autoimmune from non-autoimmune diabetes in young (15–34 years) but not in middle-aged (40–59 years) diabetic patients

@article{Bakhtadze2008CommonVI,
  title={Common variants in the TCF7L2 gene help to differentiate autoimmune from non-autoimmune diabetes in young (15–34 years) but not in middle-aged (40–59 years) diabetic patients},
  author={Ekaterine Bakhtadze and Camilla Cervin and Eero Lindholm and Henrik Borg and Peter Nilsson and Hans J Arnqvist and Jan Bolinder and Jan W Eriksson and Soffia Gudbj{\"o}rnsd{\'o}ttir and Lennarth Nystr{\"o}m and C.-D. Agardh and Mona Landin-Olsson and G{\"o}ran Sundkvist and Leif Groop},
  journal={Diabetologia},
  year={2008},
  volume={51},
  pages={2224-2232}
}
Type 1 diabetes in children is characterised by autoimmune destruction of pancreatic beta cells and the presence of certain risk genotypes. In adults the same situation is often referred to as latent autoimmune diabetes in adults (LADA). We tested whether genetic markers associated with type 1 or type 2 diabetes could help to discriminate between autoimmune and non-autoimmune diabetes in young (15–34 years) and middle-aged (40–59 years) diabetic patients. In 1,642 young and 1,619 middle-aged… CONTINUE READING

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