Common variants in the HLA-DRB1-HLA-DQA1 Class II region are associated with susceptibility to visceral leishmaniasis

  title={Common variants in the HLA-DRB1-HLA-DQA1 Class II region are associated with susceptibility to visceral leishmaniasis},
  author={Michaela Fakiola and Amy Strange and Heather J. Cordell and E. Nancy Miller and Matti Pirinen and Zhan Su and Anshuman Mishra and Sanjana Mehrotra and Gl{\'o}ria Regina G{\'o}is Monteiro and Gavin Band and C{\'e}line Bellenguez and Serge Dronov and Sarah J Edkins and Colin Freeman and Eleni Giannoulatou and Emma A Gray and Sarah E. Hunt and Henio G. Lacerda and Cordelia Langford and Richard N Pearson and N{\'u}bia N. Pontes and Madhukar Rai and Shera Prabjyot Singh and Linda K Smith and Olivia Sousa and Damjan Vukcevic and Elvira Bramon and Matthew A Brown and Juan P. Casas and Aiden P. Corvin and Audrey Duncanson and Jaroslaw Jankowski and Hugh S. Markus and Christopher G Mathew and Colin Neil Alexander Palmer and Robert Plomin and Anna Rautanen and Stephen J Sawcer and Richard C Trembath and Ananth C. Viswanathan and Nicholas Wood and Mary E Wilson and Panagiotis Deloukas and Leena Peltonen and FrankT. Christiansen and Campbell S. Witt and Selma M B Jeronimo and Shyam Sundar and Chris C A Spencer and Jenefer M Blackwell and Peter Donnelly},
  booktitle={Nature Genetics},
To identify susceptibility loci for visceral leishmaniasis, we undertook genome-wide association studies in two populations: 989 cases and 1,089 controls from India and 357 cases in 308 Brazilian families (1,970 individuals). The HLA-DRB1–HLA-DQA1 locus was the only region to show strong evidence of association in both populations. Replication at this region was undertaken in a second Indian population comprising 941 cases and 990 controls, and combined analysis across the three cohorts for… CONTINUE READING
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