Common variants in ZNF365 are associated with both mammographic density and breast cancer risk

  title={Common variants in ZNF365 are associated with both mammographic density and breast cancer risk},
  author={Sara Lindstr{\"o}m and Celine M. Vachon and Jingmei Li and Jajini Susan Varghese and Deborah J Thompson and Ruth M. L. Warren and Judith E Brown and Jean Leyland and Tina Audley and Nicholas J Wareham and Ruth J. F. Loos and Andrew D Paterson and Darryl Waggott and Lisa J Martin and Christopher G Scott and V. Shane Pankratz and Susan E. Hankinson and A. Dey Hazra and David J. Hunter and John L. Hopper and Melissa C. Southey and Stephen J. Chanock and Isabel M dos Santos Silva and Jianping Liu and Louise Eriksson and Fergus J. Couch and Jennifer Stone and Carmel Apicella and Kamila Czene and Peter Kraft and Per F L Hall and Douglas F. Easton and Norman F. Boyd and Rulla M. Tamimi},
  booktitle={Nature Genetics},
High-percent mammographic density adjusted for age and body mass index is one of the strongest risk factors for breast cancer. We conducted a meta analysis of five genome-wide association studies of percent mammographic density and report an association with rs10995190 in ZNF365 (combined P = 9.6 × 10−10). Common variants in ZNF365 have also recently been associated with susceptibility to breast cancer. 

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