Common variants in DVWA on chromosome 3p24.3 are associated with susceptibility to knee osteoarthritis

@article{Miyamoto2008CommonVI,
  title={Common variants in DVWA on chromosome 3p24.3 are associated with susceptibility to knee osteoarthritis},
  author={Yoshinari Miyamoto and Dongquan Shi and Masahiro Nakajima and K. Ozaki and Akihiro Sudo and Akihiro Kotani and Atsumasa Uchida and Toshihiro Tanaka and Naoshi Fukui and Tatsuhiko Tsunoda and Atsushi Takahashi and Yusuke Nakamura and Qing Jiang and Shiro Ikegawa},
  journal={Nature Genetics},
  year={2008},
  volume={40},
  pages={994-998}
}
Susceptibility to osteoarthritis, the most common human arthritis, is known to be influenced by genetic factors. Through a genome-wide association study using ∼100,000 SNPs, we have identified a previously unknown gene on chromosome 3p24.3, DVWA, which is associated with susceptibility to knee osteoarthritis. Expressed specifically in cartilage, DVWA encodes a 276-amino-acid protein with two regions corresponding to the von Willebrand factor type A domain (VWA domain). Several DVWA SNPs are… CONTINUE READING
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