Common variants in ABCA7 and MS4A6A are associated with cortical and hippocampal atrophy

@article{Ramirez2016CommonVI,
  title={Common variants in ABCA7 and MS4A6A are associated with cortical and hippocampal atrophy},
  author={Leslie M. Ramirez and Naira Goukasian and Shai Porat and K. Hwang and L. Apostolova},
  journal={Neurobiology of Aging},
  year={2016},
  volume={39},
  pages={82-89}
}
The precise physiologic function of many of the recently discovered Alzheimer's disease risk variants remains unknown. The downstream effects of genetic variants remain largely unexplored. We studied the relationship between the top 10 non-APOE genes with cortical and hippocampal atrophy as markers of neurodegeneration using 1.5T magnetic resonance imaging, 1-million single nucleotide polymorphism Illumina Human Omni-Quad array and Illumina Human BeadChip peripheral blood expression array data… Expand
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