Common variants in ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer’s disease

  title={Common variants in ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer’s disease},
  author={Paul Hollingworth and Denise H. Harold and Rebecca C Sims and Amy Gerrish and J C Lambert and Minerva M. Carrasquillo and R. C. Abraham and Marian L. Hamshere and Jaspreet Singh Pahwa and Valentina Moskvina and Kimberley Dowzell and Nina Jones and Alexandra Stretton and Charlene Thomas and Alex Richards and Dobril K. Ivanov and Caroline Widdowson and Jade A. Chapman and Simon Lovestone and John Francis Powell and Petroula Proitsi and Michelle K Lupton and Carol Brayne and David C Rubinsztein and Michael Gill and Brian A Lawlor and Aoibhinn Lynch and Kristelle S. Brown and Peter Anthony Passmore and David Craig and Bernadette McGuinness and Stephen Todd and Clive Holmes and David M A Mann and A. David Smith and Helen Beaumont and Donald R. Warden and G. K. Wilcock and Seth Love and Patrick Gavin Kehoe and Nigel M Hooper and Emma R. L. C. Vardy and John Hardy and Simon H Mead and Nick C. Fox and Martin Rossor and John Collinge and Wolfgang Maier and Frank Jessen and Britta Sch{\"u}rmann and Eckart Ruether and Reiner Heun and Heike Koelsch and Hendrik van den Bussche and Isabella Heuser and Johannes Kornhuber and Jens Wiltfang and Martin Dichgans and Lutz Fr{\"o}lich and Harald Hampel and Michael H{\"u}ll and J. Gallacher and Dan Rujescu and Ina Giegling and Alison M. Goate and John S. K. Kauwe and Carlos Cruchaga and P. Nowotny and John C. Morris and Kevin Mayo and Kristel Sleegers and Karolien Bettens and Sebastiaan Engelborghs and Peter Paul De Deyn and Christine Van Broeckhoven and Gill Livingston and Nicholas J Bass and Hugh M.D. Gurling and Andrew McQuillin and Rhian Gwilliam and Panagiotis Deloukas and Ammar Al-Chalabi and Christopher E. Shaw and Magda Tsolaki and Andrew Singleton and R Guerreiro and Thomas W. M{\"u}hleisen and Markus M. N{\"o}then and Susanne Moebus and Karl-Heinz J{\"o}ckel and Norman Klopp and Heinz-Erich Wichmann and V. Shane Pankratz and Sigrid Botne Sando and Jan O Aasly and Maria Barcikowska and Zbigniew K Wszolek and Dennis W. Dickson and Neill R. Graff-Radford and Ronald C. Petersen and Cornelia M van Duijn and Monique M. B. Breteler and M. Arfan Ikram and Anita L. DeStefano and Annette L. Fitzpatrick and Oscar L. Lopez and Lenore J. Launer and Sudha Seshadri and C Berr and Dominique Campion and Jacques Epelbaum and J F Dartigues and Christophe Tzourio and Annick Alp{\'e}rovitch and Mark Lathrop and Thomas M Feulner and Patricia Friedrich and Caterina Riehle and Michael Krawczak and Stefan Schreiber and Manuel Mayhaus and S Nicolhaus and Stefan Wagenpfeil and Stacy Steinberg and Hreinn Stefansson and K{\'a}ri Stef{\'a}nsson and J{\'o}n Sn{\ae}dal and Sigurbj{\"o}rn Bj{\"o}rnsson and Palmi V. Jonsson and Vincent Chouraki and Benjamin Genier-Boley and Mikko Hiltunen and Hilkka Soininen and Onofre Combarros and Diana Z{\'e}l{\'e}nika and Marc D{\'e}l{\'e}pine and Mar{\'i}a J Bullido and Florence Pasquier and Ignacio Mateo and Ana Frank-Garc{\'i}a and Elisa Porcellini and Olivier Hanon and Eliecer Coto and V. Gonz{\'a}lez {\'A}lvarez and P. I. Bosco and Gabriele Siciliano and M Mancuso and Francesco Panza and Vincenzo Solfrizzi and Benedetta Nacmias and Sandro Sorbi and Paola Boss{\`u} and Paola Piccardi and Beatrice Arosio and Giorgio Annoni and Davide Seripa and Alberto Pilotto and Elio Scarpini and Daniela Galimberti and Alexis Brice and Didier Hannequin and Federico Licastro and Lesley Jones and Peter Holmans and Thorl{\'a}kur J{\'o}nsson and Matthias Riemenschneider and Kevin A Morgan and Steven G. Younkin and Michael J Owen and Michael C. O’Donovan and Philippe Amouyel and Julie Williams},
  booktitle={Nature Genetics},
We sought to identify new susceptibility loci for Alzheimer's disease through a staged association study (GERAD+) and by testing suggestive loci reported by the Alzheimer's Disease Genetic Consortium (ADGC) in a companion paper. We undertook a combined analysis of four genome-wide association datasets (stage 1) and identified ten newly associated variants with P ≤ 1 × 10−5. We tested these variants for association in an independent sample (stage 2). Three SNPs at two loci replicated and showed… CONTINUE READING
Highly Influential
This paper has highly influenced 42 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Recent Discussions
This paper has been referenced on Twitter 2 times over the past 90 days. VIEW TWEETS


Publications citing this paper.
Showing 1-10 of 407 extracted citations


Publications referenced by this paper.
Showing 1-10 of 38 references

Alzheimer’s Disease Neuroimaging Initiative (ADNI): clinical characterization

  • RC Petersen
  • Neurology
  • 2010

Association of CLU and PICALM variants with Alzheimer’s disease

  • MI Kamboh
  • Neurobiol Aging
  • 2010

Genetic variation and neuroimaging measures in Alzheimer disease

  • A Biffi
  • Arch Neurol
  • 2010

Genome-wide analysis of genetic loci associated with Alzheimer disease

  • S Seshadri
  • JAMA
  • 2010

Similar Papers

Loading similar papers…