Common variants at MS 4 A 4 / MS 4 A 6 E , CD 2 AP , CD 33 and EPHA 1 are associated with late-onset Alzheimer ’ s disease

  title={Common variants at MS 4 A 4 / MS 4 A 6 E , CD 2 AP , CD 33 and EPHA 1 are associated with late-onset Alzheimer ’ s disease},
  author={Gyungah Jun and Gary W. Beecham and Li-San Wang and Badri Narayan Vardarajan and Jacqueline Buros and Paul J. Gallins and Joseph D. Buxbaum and Gail P. Jarvik and Paul K Crane and Eric B. Larson and Thomas Bird and Bradley F. Boeve and Neill R. Graff-Radford and Philip L. De Jager and Denis E Evans and Julie A Schneider and Minerva M. Carrasquillo and Nil{\"u}fer Ertekin-Taner and Steven G. Younkin and Carlos Cruchaga and John S. K. Kauwe and P. Nowotny and Patricia Kramer and John S. Hardy and Matthew J. Huentelman and Amanda J. Myers and M. Michael Barmada and Fatma Yesim Demirci and C. T. Baldwin and Robert C Green and Ekaterina A. Rogaeva and Peter H. St George-Hyslop and Steven E Arnold and Robert Barber and Thomas Gerald Beach and Eileen Bigio and J D Bowen and Adam L. Boxer and James R Burke and Nigel J. Cairns and Christopher S Carlson and Regina M. Carney and Steven L. Carroll and Helena Chang Chui and David Glenn Clark and Jason J. Corneveaux and Carl Cotman and Jeffrey L. Cummings and Charles DeCarli and Steven DeKosky and Ramon Diaz-Arrastia and Malcolm C Dick and Dennis W. Dickson and W. J. Ellis and Kelley M. Faber and Kenneth B. Fallon and Martin R. Farlow and Steven J. Ferris and Matthew P. Frosch and Douglas R. Galasko and Mary Ganguli and Marla Gearing and Daniel H. Geschwind and Bernardino Ghetti and John R. Gilbert and Sid Gilman and Bruno Giordani and Jonathan D. Glass and John Growdon and Ronald L. Hamilton and Lindy E. Harrell and Elizabeth Head and Lawrence S. Honig and Christine M. Hulette and Bradley T. Hyman and Gregory A. Jicha and Lee-way Jin and Nancy Johnson and Jason H. T. Karlawish and Anna M. Karydas and Jeffrey A. Kaye and Ronald Kim and Edward H. Koo and Neil W. Kowall and James J Lah and Allan I. Levey and Andrew P. Lieberman and Oscar L. Lopez and Wendy J. Mack and Daniel C. Marson and Frank T. Martiniuk and Deborah C. Mash and Eliezer Masliah and Wayne C. McCormick and Susan M McCurry and Andrew N. McDavid and Ann C. McKee and M - Marsel Mesulam and Bruce L. Miller and Carol Ann Miller and Joshua W. Miller and Joseph E. Parisi and Daniel P. Perl and E. R. Peskind and Ronald C. Petersen and Wayne W S Poon and Joseph F Quinn and Ruchita A Rajbhandary and Murray Raskind and Barry Reisberg and John M. Ringman and Erik D Roberson and Roger N. Rosenberg and Mary C Sano and L. S. Schneider and William W. Seeley and Michael L Shelanski and Michael A. Slifer and Charles D. Smith and Joshua A. Sonnen and Salvatore Spina and Robert A. Stern and Rudolph E. Tanzi and John Q. Trojanowski and Juan C Troncoso and Vivianna M. D. Van Deerlin and H V Vinters and Jean Paul G. Vonsattel and Sandra Weintraub and Kathleen Welsh-Bohmer and Jennifer Elaine Williamson and Randall L. Woltjer and Laura B. Cantwell and Beth A. Dombroski and Duane L. Beekly and Kathryn L. Lunetta and Eden R. Martin and M. Ilyas Kamboh and Andrew J. Saykin and Eric M. Reiman and David A. Bennett and John C. Morris and Thomas J. Montine and Alison M. Goate and Deborah Blacker and Debby W. Tsuang and Hakon Hakonarson and Walter Kukull and Tatiana Foroud and Jonathan L. Haines and Richard Mayeux and Margaret A. Pericak-Vance and Lindsay A. Farrer and Gerard D. Schellenberg},
The Alzheimer Disease Genetics Consortium (ADGC) performed a genome-wide association study of late-onset Alzheimer disease using a three-stage design consisting of a discovery stage (stage 1) and two replication stages (stages 2 and 3). Both joint analysis and meta-analysis approaches were used. We obtained genome-wide significant results at MS4A4A (rs4938933; stages 1 and 2, meta-analysis P (PM) = 1.7 × 10−9, joint analysis P (PJ) = 1.7 × 10−9; stages 1, 2 and 3, PM = 8.2 × 10−12), CD2AP… CONTINUE READING
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