Common variants at 6p21.1 are associated with large artery atherosclerotic stroke

  title={Common variants at 6p21.1 are associated with large artery atherosclerotic stroke},
  author={Elizabeth G. Holliday and Jane Margaret Maguire and Tiffany-Jane Evans and Simon Andrea Koblar and Jim Jannes and Jonathan William Sturm and Graeme J. Hankey and Ross Baker and Jonathan Golledge and Mark William Parsons and Rainer Malik and Mark McEvoy and Erik Biros and Martin David Lewis and Lisa F Lincz and Roseanne Peel and Christopher Oldmeadow and Wayne Smith and Pablo A Moscato and Simona Barlera and Steve N Bevan and Joshua C Bis and Eric Boerwinkle and Giorgio Boncoraglio and Thomas Brott and R. D. Brown and Y C Cheng and John W. Cole and Ioana Cotlarciuc and William J. Devan and Myriam Fornage and Karen L. Furie and S{\'o}lveig Gr{\'e}tarsd{\'o}ttir and Andreas Gschwendtner and M. Arfan Ikram and W. T. Longstreth and James F Meschia and Braxton D. Mitchell and Thomas H. Mosley and Michael A. Nalls and Eugenio Agostino Parati and Bruce M. Psaty and Pankaj Sharma and K{\'a}ri Stef{\'a}nsson and Gudmar Thorleifsson and Unnur Thorsteinsdottir and Matthew Traylor and Benjamin F. J. Verhaaren and Kerri L Wiggins and Bradford Worrall and Cathie L. M. Sudlow and Peter M. Rothwell and Martin Farrall and Martin Dichgans and Jonathan Rosand and Hugh S. Markus and Rodney J. Scott and Christopher Royce Levi and John Attia},
  journal={Nature Genetics},
Genome-wide association studies (GWAS) have not consistently detected replicable genetic risk factors for ischemic stroke, potentially due to etiological heterogeneity of this trait. We performed GWAS of ischemic stroke and a major ischemic stroke subtype (large artery atherosclerosis, LAA) using 1,162 ischemic stroke cases (including 421 LAA cases) and 1,244 population controls from Australia. Evidence for a genetic influence on ischemic stroke risk was detected, but this influence was higher… CONTINUE READING
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