Common variants associated with general and MMR vaccine-related febrile seizures

  title={Common variants associated with general and MMR vaccine-related febrile seizures},
  author={Bjarke Feenstra and Bj{\"o}rn Pasternak and Frank Geller and Lisbeth Carstensen and Tongfei A Wang and Fen Huang and Jennifer L. Eitson and Mads Vilhelm Hollegaard and Henrik Svanstr{\"o}m and Mogens Vestergaard and David Michael Hougaard and John W Schoggins and Lily Yeh Jan and Mads Melbye and A Hviid},
  booktitle={Nature Genetics},
Febrile seizures represent a serious adverse event following measles, mumps and rubella (MMR) vaccination. We conducted a series of genome-wide association scans comparing children with MMR-related febrile seizures, children with febrile seizures unrelated to vaccination and controls with no history of febrile seizures. Two loci were distinctly associated with MMR-related febrile seizures, harboring the interferon-stimulated gene IFI44L (rs273259: P = 5.9 × 10−12 versus controls, P = 1.2 × 10−9… CONTINUE READING

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