Common variable immunodeficiency. Old questions are getting clearer.

  title={Common variable immunodeficiency. Old questions are getting clearer.},
  author={Alfredo A Blanco-Quir{\'o}s and P Sol{\'i}s-S{\'a}nchez and Jos{\'e} Antonio Garrote-Adrados and Eduardo Arranz-Sanz},
  journal={Allergologia et immunopathologia},
  volume={34 6},
Common variable immunodeficiency (CVID) is a heterogeneous entity characterized by an impaired ability to produce antibodies. The failure is localized in partially mature B lymphocytes, though T lymphocyte abnormalities are occasionally present. This deficiency affects antibody synthesis and class switch from IgD and IgM, to IgG and IgA. CVID is related to selective IgA deficiency, and both abnormalities may coincide in one same family, and evolve from one to another in the same patient. The… CONTINUE READING


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An antibodydeficiency syndrome due to mutations in the CD 19 gene

M vanZelm, I Reisli, +3 authors van Tol MJD
N Engl J Med • 2006

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