Common variable immunodeficiency: an update on etiology and management.

  title={Common variable immunodeficiency: an update on etiology and management.},
  author={Patrick F. K. Yong and Michael D Tarzi and Ignatius Chua and Bodo Grimbacher and Ronnie Chee},
  journal={Immunology and allergy clinics of North America},
  volume={28 2},
  pages={367-86, ix-x}
Common variable immunodeficiency (CVID) represents a heterogeneous group of primary antibody deficiency disorders characterized by recurrent infection and by inflammatory, granulomatous, and autoimmune complications. Recently, there have been significant advances in understanding the pathogenesis of the disease, with five genetic mutations identified in patients who have a CVID phenotype. Clinical care also has progressed with refinements in treatment and the development of classification… CONTINUE READING


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