Common themes in siRNA-mediated epigenetic silencing pathways.

  title={Common themes in siRNA-mediated epigenetic silencing pathways.},
  author={Andr{\'e} Verdel and Aur{\'e}lia Vavasseur and Madalen Le Gorrec and Leila Touat-Todeschini},
  journal={The International journal of developmental biology},
  volume={53 2-3},
Small interfering RNAs (siRNAs) act through RNA interference (RNAi) pathways to silence gene expression either at the transcriptional or post-transcriptional level. Here, we review mechanisms and functions of siRNA-mediated silencing pathways that promote chromatin modifications in the fission yeast Schizosaccharomyces pombe, plants and animals. In fission yeast, siRNAs are involved in heterochromatin formation and key aspects of the underlying siRNA-dependent pathway have been uncovered. Two… CONTINUE READING
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