Common subunits of cytokine receptors and the functional redundancy of cytokines.

@article{Miyajima1992CommonSO,
  title={Common subunits of cytokine receptors and the functional redundancy of cytokines.},
  author={Atsushi Miyajima and Takeshi Wako Hara and Takayuki Kitamura},
  journal={Trends in biochemical sciences},
  year={1992},
  volume={17 10},
  pages={
          378-82
        }
}
Several distinct cytokines often exhibit similar biological activities. The findings that high-affinity receptors for a group of cytokines with similar function share a common subunit with a critical role in signal transduction have provided a molecular basis for the functional redundancy of cytokines. Since the common subunit, together with distinct cytokine-specific receptor subunits, form high-affinity receptors, binding of one cytokine to its high-affinity receptor can be competed for by… CONTINUE READING
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